WC10 a cutting edge scientific meeting with emphasis on the latest technologies for reduction and replacement of animals and innovations in approaches to ethics, animal welfare and public policy. Its focus is on the Three Rs. The occurrence of the 10th in a series of World Congresses in the area of Alternatives and Animal Use in the Life Sciences is a milestone and correlates with the 10th anniversary of the National Research Council report on Toxicity Testing in the 21st Century – A Vision and a Strategy.